3,3-difluorocyclobutanaMine dihydrochloride

3,3-difluorocyclobutanaMine dihydrochloride - Names and Identifiers

Name	3,3-Difluorocyclobutanamine
Synonyms	OBUTANAMINE 3,3-DIFLUROCYCLOBUTANAMINE 3,3-Difluorocyclobutanamine cyclobutanamine, 3,3-difluoro- CyclobutanaMine, 3,3-difluoro- 3,3-difluorocyclobutan-1-aMine 1-Amino-3,3-difluorocyclobutane Cyclobutanamine, 3,3-difluoro- (9CI) 3,3-difluorocyclobutanaMine dihydrochloride
CAS	791061-00-2

3,3-difluorocyclobutanaMine dihydrochloride - Physico-chemical Properties

Molecular Formula	C4H7F2N
Molar Mass	107.1
Density	1.17
Boling Point	83℃
Flash Point	-11℃
Storage Condition	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

3,3-difluorocyclobutanaMine dihydrochloride - Reference Information

Introduction

3, 3-difluorocyclobutylamine is a pharmaceutical intermediate that can be used to prepare Ivosidenib. On July 20, 2018, cancer biopharmaceutical company Agios Pharmaceuticals announced that its anticancer drug Ivosidenib (trade name Tibsovo) was approved by the US FDA for the presence of susceptible isocitrate dehydrogenase -1(IDH1). In adults with relapsed or refractory acute myeloid leukemia (R/R AML), Tibsovo is an orally targeted inhibitor of the IDH1 enzyme, it is also the first and only FDA-approved drug for the treatment of IDH1 mutant R/R AML.

Use

3, 3-difluorocyclobutylamine belongs to Amine Derivatives and is used as a pharmaceutical intermediate.

Last Update：2024-04-10 22:29:15